These 4 Thyroid Health Supplements Can Help Boost Metabolism, Energy, Focus, Digestion, and More.

Plus, what goes into a quality thyroid supplement (and what to avoid.)
Feeling like you're dragging yourself through the day? Dealing with brain fog? Stubborn weight that won't budge no matter what you do? 

Before you chalk it up to "just getting older," there's something you should know about a tiny gland that could be behind it all – your thyroid. 

Your thyroid is your body's power plant. It pumps out hormones T3 and T4 that control everything from your energy levels and metabolism to your digestion and even your breathing. When it's working right, you feel great. When it's not? That's when the trouble starts.

Unfortunately, modern lifestyles aren’t exactly thyroid-friendly. Processed foods and depleted soil conditions have stripped our diet of the vital nutrients our thyroids need to function properly. As a result, it struggles to produce hormones at a sufficient rate, and many people find themselves dealing with constant exhaustion, a mind that always feels foggy, and extra pounds that seem impossible to lose.

The good news is, a combination of diet, exercise, and a well-rounded supplement can assist your thyroid's natural ability to produce healthy levels of T3 and T4, helping to boost your mood, speed up your metabolism, and improve your mental clarity.

How To Identify Effective Thyroid Supplements from Junk

According to the American Thyroid Association, an estimated 20 million Americans have some form of thyroid issue, and women are up to 8 times more likely to be affected. No wonder there are so many thyroid supplements out there. But they aren’t all created equal; how do you know what actually works?

When considering a supplement you need something you can trust, from the ingredients to the company. Quality is a serious concern. Many companies are rushing to cash in, flooding stores with products that contain cheap fillers instead of research-backed ingredients with proven results.

That’s why our research team analyzed the most popular thyroid formulas on the market. We discovered many products making bold promises that seem too good to be true. 

So today we’ll cut through the marketing hype and share what actually works, what to avoid, and what to look for in a high-quality thyroid supplement.

And most importantly, what kind of results you can actually expect.

What Kind of Results To Expect And When

While you might notice some positive changes within the first month, giving your body time to fully restore optimal thyroid hormone levels is key.

Our research shows that taking a thyroid supplement daily for 3 months can provide maximum support for your mood, metabolism, and mental clarity and significantly increase the likelihood of lasting results.

With that said, here’s a realistic timeline of what you can expect:

First 30 days:
  • Improved Energy Levels
  • Brighter Mood
  • Less Irritable
60 days in: 
  • Sharper Mental Clarity 
  • Clothes fitting better
  • Weight begins normalizing
90 days and beyond:
  • Full thyroid support achieved
  • Sustained energy levels
  • Stable weight management
  • Consistent mental clarity
Pro Tip: Think of thyroid support like building momentum - each day builds on the last. The key to success? Consistency. Taking a high-quality formula with proven ingredients everyday for at least 3 months allows your body to reach optimal thyroid support levels.

The 7 Must-Have Ingredients For A Quality Thyroid Supplement

#1: Selenium

Your thyroid uses more selenium than any other organ in your body. This mineral powers your thyroid’s ability to make T3 and T4. That’s why getting enough selenium is vital to the health of your thyroid. A study from the American Thyroid Association found selenium supplementation is associated with improvement in mood and or general well-being. And a study published in the International Journal of Endocrinology proved maintaining a physiological concentration of selenium is a prerequisite to preventing thyroid disease and preserving overall health.

#2: Zinc

Zinc helps activate T4 into T3, which is the only usable form for your cells. Zinc also helps support a healthy immune system, helps stabilize thyroid hormone levels, and can help regrow lost hair. Research shows zinc fortifies your immune system, which is important for those suffering from thyroid issues.

#3: Copper

Copper is vital to energy production in your cells. Without it, your cells can’t turn T3 into energy. That’s why a copper deficiency is one of the biggest causes of brain fog in women. Studies show copper helps improve focus, memory, and learning. It also helps you feel less weak, sluggish, and tired.

#4: Guggul

Guggul is a flower resin that’s been used in Ayurvedic medicine for over 2500 years. A study out of Phytotherapy Research Journal found that guggul helps the thyroid uptake more nutrients. In other words, it increases absorption of the rest of the nutrients in any formula. Many thyroid supplements don’t include this powerful herb simply because of the effort required to find a quality source.

#5: Ashwagandha

Ashwagandha is an adaptogenic herb that balances stress in the body. It’s been used in Ayurvedic medicine for over 5000 years because of its strong link to thyroid health in women and is backed by over 22,000 studies that show that this powerful herb stimulates healthy thyroid activity.

#6: L-tyrosine

L-tyrosine is an amino acid that serves as a precursor to the key thyroid hormones that help regulate crucial metabolic processes throughout the body. By providing your body with the building blocks of T3 and T4, L-tyrosine helps support your thyroid’s natural production of these essential hormones. This helps boost your energy levels, reduce bloating and puffiness, and clear away brain fog.

#7: Vitamin A

It might sound like the least interesting ingredient, but make no mistake vitamin A is critical for healthy thyroid function. Studies show that vitamin A helps your liver activate T4 into T3. In one study, it made a dramatic difference in T3 levels in women, which is a good thing if you want energy and a fast metabolism.

Now let's talk about red flags to be on the lookout for when choosing a thyroid support supplement.

Warning Signs of Ineffective Supplements

Filler Ingredients

Most supplements simply don’t have high quality sources of ingredientsQuality thyroid ingredients are expensive and require precise sourcing, yet there’s only so much space in a single capsule. So manufacturers try to pack cheaper, less potent ingredients into one pill to keep costs down. The result? Lower-quality compounds that look good on the label but deliver minimal benefits. The most effective thyroid formulas focus on select, proven ingredients in their optimal forms and prioritize quality over quantity, ensuring each component can deliver real results.

Not A Targeted Formula

Many thyroid supplements lack ingredients specifically formulated for low thyroid function. They offer generic “thyroid support” without addressing the unique nutrient deficiencies that cause thyroid issues. A true low-thyroid formula needs targeted compounds that help restore T3 and T4 production and boost hormone conversion. Without these specific nutrients, supplements can’t effectively address the root cause of thyroid issues.

Not made in a cGMP certified facility

cGMP stands for Current Good Manufacturing Practice Regulations and is a set of regulations enforced by the Food and Drug Administration (FDA). Manufacturing facilities use it to ensure proper quality, purity, design, and control of their manufacturing processes. But the reason cGMP is so important is that you really have no way to detect through sight, smell, or touch what is in your supplements, if they will work, or if they are even safe for consumption. Basically, you have no way of knowing or determining if the product you’re taking actually contains what it claims to include. cGMP regulations help reduce the risk of contamination, errors, or inconsistencies in the final product, and helps certify that what the bottle claims on the label is actually in it. That’s why when shopping for supplements, always make sure it’s produced in a cGMP certified facility.

The Top 4 Thyroid Supplements of 2025

Here is a side-by-side comparison based on our research and analysis of the top thyroid support formulas available today.
Now we’ll break down our rankings and provide detailed reviews of the 4 best thyroid health products we analyzed. Let’s begin with our #1 pick.

1. Thyroid Renew

by Bright Naturals

Our Rating

A+

Overall Grade

Pros

Exclusive up to 42% discount

Contains all 7 must-have ingredients

Targeted formula tackles the root cause of low thyroid

No fillers or artificial additives

Vegan, non-GMO, and gluten-free

Made in a cGMP-certified facility here in the USA

Cons

Available online, but not currently sold in retail stores

The Bottom Line

Thyroid Renew by Bright Naturals received our #1 ranking because it is the only thyroid health supplement that meets every one of our strict criteria.

Thyroid Renew is made in a cGMP certified facility right here in the United States with ingredients traced back to the source.

Thyroid Renew contains all 7 of the ingredients we consider essential for optimal thyroid support, including Selenium, Zinc, Copper, Ashwagandha, Guggul, L-tyrosine, and Vitamin A.

Each of the ingredients in this targeted formula were specifically chosen because of their science-backed ability to address the unique nutrient deficiencies that cause low thyroid issues.

It is available on Amazon.com, but we found significantly better discounts on Bright Natural's website. The company also offers other products for issues related to a sluggish thyroid, including liver support, a natural anxiety remedy, and a cognitive enhancement supplement.

Overall, Thyroid Renew is our top pick for supporting thyroid health in 2025.

2. T-150

by Xymogen

Our Rating

A-

Overall Grade

Pros

Contains 2 out of 7 must-have ingredients

No artificial additives

Non-GMO and gluten-free

Made in the USA

Cons

Does not contain 5 out of 7 must-have ingredients

Contains several glandular extracts from bovine organs, which have little therapeutic benefit due to safety processing

Not vegetarian

The Bottom Line

The Bottom Line T-150 by Xymogen provides effective thyroid support with a strong cast of ingredients that includes 2 of the primary components that we look for in a quality thyroid supplement: L-tyrosine and Selenium

In addition, T-150 contains a number of glandular extracts from bovine organs, including thyroid gland. This approach to natural medicine takes inspiration from the concept of "like helps like" that dates back to ancient times. However, because these harvested organs typically contain unpredictable concentrations of animal hormones, glandular extracts are highly processed to render them safe for human consumption. Unfortunately, this procedure eliminates much of their therapeutic benefit.

The space occupied in the formula by these largely inactive extracts might be better utilized by ingredients with proven efficacy for thyroid health, such as the combination of Guggul and Zinc. 

3. Thyroid Synergy

by Designs for Health

Our Rating

B+

Overall Grade

Pros

Contains a form of L-tyrosine that is easily absorbed

No artificial additives

Vegetarian, non-GMO, and gluten-free

Made in the USA

Cons

Does not contain 2 out of 7 must-have ingredients

Contains some ingredients with questionable efficacy

The Bottom Line

The Bottom Line Thyroid Synergy by Designs for Health features one of the single most important compounds for effective thyroid support, L-tyrosine, in the form of N-acetyl-L-tyrosine. This is a more bioavailable and easily absorbed version of the essential amino acid than was provided by the other supplements we reviewed.

Despite this strong core ingredient, Thyroid Synergy is missing 2 of the 7 ingredients we consider to be crucial for effective thyroid support. Ashwagandha and Guggul are absent from the formula. On top of that, its iodine content is provided by commercially produced potassium iodide. If not carefully administered, this compound can deliver significantly more iodine than is healthy for an individual struggling with a low thyroid.

Given that the product's claims have not been verified by an independent, third-party clinical study, it is surprising that Designs for Health decided to include American ginseng and forskolin, both of which have limited proof of efficacy for thyroid health. With better options available that are supported by a greater body of scientific evidence, the formula's composition represents a bit of a missed opportunity.

4. Thyrosol

by Metagenics

Our Rating

B

Overall Grade

Pros

No artificial additives

Vegan, non-GMO, and gluten-free

Made in the USA

Cons

Does not contain 4 of our 7 must-have ingredients

Contains beneficial vitamins and minerals, but they may conflict with a daily multivitamin

The Bottom Line

Thyrosol by Metagenics is supported by vitamins, minerals, and the stress-relieving herb rhodiola rosea. 

While the broad array of vitamins and minerals in this formula can improve thyroid health, most modern diets already contain sufficient quantities to maintain proper thyroid function.

 Moreover, if you are taking a daily multivitamin, taking Thyrosol in addition may result in higher than recommended consumption of certain vitamins and minerals.

Rounding out the formula is rhodiola rosea, a natural anxiety remedy with some promising clinical studies supporting its effectiveness. While mental and physical stress are closely associated with thyroid issues, they are side effects of a sluggish thyroid rather than the cause. The inclusion of rhodiola rosea may merely mask thyroid issues rather than resolving the underlying problem.
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